![]() About 20% of patients with type 1 AIP have normal levels of IgG4 in the serum 10. It should be noted, however, that the levels of this particular IgG subtype are not always useful for the differential diagnosis or evaluation of disease severity in IgG4-RD and type 1 AIP. Thus, the measurement of serum IgG4 concentration is useful not only for the diagnosis but also for the evaluation of disease severity in IgG4-RD. Moreover, serum IgG4 concentration over 280 mg/dL is associated with multiple organ involvement and the risk of relapse 8, 9. Now AIP is classified into type 1 and type 2 AIP, the former being the pancreatic manifestation of IgG4-RD 5.Įlevated IgG4 serum levels are a diagnostic marker for type 1 AIP and IgG4-RD 6, 7. The clinicopathological features of IgG4-RD were first identified in patients with autoimmune pancreatitis (AIP) and then, various kinds of autoimmune diseases formerly classified as AIP, autoimmune sialadenitis, autoimmune sclerosing cholangitis, and retroperitoneal fibrosis, have become recognized as organ-specific manifestations of systemic IgG4-RD 1, 2, 3, 4. This autoimmune disorder is also characterized by multiple organ involvement 1, 2, 3. IgG4-related disease (IgG4-RD) is a recently discovered autoimmune disorder characterized by elevated IgG4 serum levels and by the accumulation of IgG4-expressing plasmacytes in the affected organs 1, 2, 3. We conclude that serum IFN-α and IL-33 concentrations can be useful as biomarkers for type 1 AIP and IgG4-RD. Induction of remission by prednisolone treatment markedly decreased the serum concentration of these cytokines. Diagnostic performance of serum IFN-α and IL-33 concentrations as markers of type 1 AIP and/or IgG4-RD was comparable to that of serum IgG4 concentration, as calculated by the receiver operating characteristic curve analysis. Strong correlations between serum IFN-α, IL-33, and IgG4 concentrations were observed. Serum IFN-α and IL-33 concentrations in patients who met the diagnostic criteria for definite type 1 AIP and/or IgG4-RD were significantly higher than in those with chronic pancreatitis or in healthy controls. In this study, we assessed the utility of serum IFN-α and IL-33 levels as biomarkers for type 1 AIP and IgG4-RD. Recently, we reported that the development of experimental AIP and human type 1 AIP is associated with increased expression of IFN-α and IL-33 in the pancreas. Although serum IgG4 concentration is widely used as a biomarker for IgG4-RD and type 1 autoimmune pancreatitis (AIP), a pancreatic manifestation of IgG4-RD, a significant number of patients have normal serum IgG4 levels, even in the active phase of the disease. IgG4-related disease (IgG4-RD) is a multi-organ autoimmune disease characterized by elevated serum IgG4 concentration. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |